HCID 22601390, compound → HCID 22601475, compound

HRID 970904Notes

Reaction equation

HRID 970904 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([S:9]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1>C(Cl)Cl.O=[Mn]=O>[CH:2]([C:3]1[CH:4]=[C:5]([S:9]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1)=[O:1]

Participants

4

Reactant 1

HCID 22601390HCID 22601390, compound

Product 1

HCID 22601475HCID 22601475, compoundYield 82.5%

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Procedure

Reaction of 3-Hydroxymethyl-N-phenyl-benzenesulfonamide (crude from previous step, 1.36 mmol), MnO2 (1.40 g, 13.60 mmol) in CH2Cl2 (10 mL) at 40° C. under N2 overnight gave the title compound (293 mg, 82%) as a white solid.

Sources & evidence

ORD record
ord-8a25eb986f084954a3235f328ffcd5c0
Source dataset
uspto-grants-2007_12
Patent number
US07312234B2

Reaction notes

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