Phenyl isocyanate → HCID 10118654, compound

Participants

Reaction Steps

To a cold (0° C.) solution of (4-aminomethyl-benzyl)-(1H-benzimidazol-2-ylmethyl)-(5,6,7,8-tetrahydro-quinolin-8-yl)-amine (0.136 g, 0.34 mmol) in CH2Cl2 (3.5 mL) was added phenyl isocyanate (41 μL, 0.38 mmol) and the resultant solution was stirred for 50 minutes. The cooling bath was removed and the mixture was concentrated under reduced pressure. Purification of the crude material by column chromatography on silica gel (25:1:1 CH2Cl2—CH3OH—NH4OH) provided the free base of the title compound (0.127 g, 72%) as a white solid.

Provenance & Evidence