Picolinic acid → HCID 10117948, compound

Participants

Reaction Steps

Using the EDCI coupling general procedure F: Reaction of (3-aminomethyl-benzyl)-1H-benzimidazol-2-ylmethyl)-(5,6,7,8-tetrahydro-quinolin-8-yl)-amine (133 mg, 0.33 mmol), picolinic acid (40 mg, 0.33 mmol), 1-hydroxybenzotriazole (45 mg, 0.33 mmol), DIPEA (100 uL, 0.57 mmol), and EDCI (64 mg, 0.33 mmol) in anhydrous DMF (3 mL) for 3 d at room temperature followed by purification of the crude material by chromatography on silica gel (2:2:96 CH3OH—NH3 H2O—CH2Cl2) afforded the title compound (158 mg, 94%) as a white foam.

Provenance & Evidence