Hydrochloric Acid → HCID 14346299, compound

Participants

Reaction Steps

A solution of 1.00 g (3.99 mmol) of compound 10 obtained in the preceding stage in 50 ml of absolute ethanol is brought to reflux. 10 ml of a 35% aqueous hydrochloric acid solution are added in small amounts. Reflux is maintained for 48 hours. After evaporation of the solvents, the residue is taken up in the minimum amount of ice-cold ethanol. The precipitate formed is filtered off and washed with ice-cold methanol. The filtrate is evaporated and then the residue is taken up in the minimum amount of methanol. The precipitate formed is filtered off and washed with ice-cold methanol. Compound 11·4HCl is isolated in the form of a white powder (0.80 g, Yd =57%).

Provenance & Evidence