Glyoxal → HCID 23290139, compound

HRID 970952Notes

Reaction equation

HRID 970952 reaction equation
[CH:1]([CH:3]=O)=O.[NH2:5][CH2:6][CH2:7][NH:8][CH2:9][CH2:10][CH2:11][NH:12][CH2:13][CH2:14][NH2:15]>O>[NH:15]1[C:1]2=[C:3]3[N:8]([CH2:7][CH2:6][NH:5]2)[CH2:9][CH2:10][CH2:11][N:12]3[CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 7860GlyoxalHCID 78479N,N'-Bis(2-aminoethyl)-1,3-propanediamine

Product 1

HCID 23290139HCID 23290139, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

9.04 g (62.4 mmol) of a 40% by weight aqueous glyoxal solution are slowly added dropwise to a solution of 10.00 g (62.4 mmol) of N,N′-bis(2-aminoethyl)-1,3-pro-panediamine in 30 ml of water at 0° C. The mixture is maintained at this temperature for 1 hour and then stirred at ambient temperature for 10 hours. After evaporation of the water, compound 12 is isolated quantitatively in the form of a pale yellow solid and is used for the following stage without subsequent purification.

Workup

  1. temperatureThe mixture is maintained at this temperature for 1 hour
  2. customAfter evaporation of the water

Sources & evidence

ORD record
ord-64eb637340ab4cd993c030445d46316d
Source dataset
uspto-grants-2007_12
Patent number
US07312327B2

Reaction notes

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