Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → N-(2quinolinylcarbonyl)-L-isoasparagine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Bicarbonate Ion | HCID 769 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Quinaldic Acid | HCID 7124 | — |
| 반응물 | Isoasparagine | HCID 7015702 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | N-(2quinolinylcarbonyl)-L-isoasparagine | HCID 59936550 | 70% |
반응 단계
To a solution of 0.50 g (3.78 mmol) of L-isoasparagine in 5.0 mL H2O containing ˜45 mg (1.5 eq) of solid bicarbonate. To this was added a suspension of 1.02 g (3.78 mmol) quinaldic acid, N-hydroxysuccinamide ester in ethylene glycol dimethylether, and the suspension was solubilized by the addition of 10 mL of dimethylformamide. After 3 hours the solution was acidified by the addition of 5% HCl (aqueous) and the product was filtered and washed with water, dried under vacuum to yield 750 mg (70% yield) of N-(2-quinolinylcarbonyl)-L isoasparagine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07312333B2 |
| 출처 데이터셋 | uspto-grants-2007_12 |
| ORD ID | ord-9f52a406bc2042b5910461ce5236f60b |
| 출처 메모 | uspto-grants-2007_12 |