HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dibromopyridine → 5-Bromo-2-(methylthio)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dibromopyridine | HCID 69353 | — |
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Bromo-2-(methylthio)pyridine | HCID 11424251 | — |
Reaction Steps
A mixture of 2,5-dibromopyridine and sodium thiomethoxide (1.3 eq) in N,N-dimethylformamide (2 ml/mmol) was stirred at room temperature for 20 minutes then cooled to 0° C. After diluting with cold water the precipitate was filtered to afford the 5-Bromo-2-methylthiopyridine compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07312334B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-805be5141cb245fd9a79796a7abfd520 |
| Source note | uspto-grants-2007_12 |