Acetyl chloride → HCID 11571860, compound

Temperature

15 °C

13.1 g Crude Boc-N-methyl-alaninal (70 mmol) were dissolved in 100 ml methanol and cooled to ˜15° C. A solution of 11 g (140 mmol) acetyl chloride in 30 ml methanol was added all at once and the yellowish solution was stirred at RT for 1 h (gas evolution). 67.52 g Trimethyl orthoformate (630 mmol) were now added and the reaction mixture was stirred at RT over night (18 h). The solvent and the excess of the orthoester were removed by rotary evaporation (40° C./≧10 mbar) and the resulting 11.9 (100%) beige, crystalline residue was crystallized from 120 ml hot isopropyl acetate yielding after stirring at −20° C. for 17 h 8.4 g (71%) beige product, [α]D=10.8 (CHCl3; c=1). 1H-NMR:

1. stirringthe reaction mixture was stirred at RT over night (18 h)
2. customThe solvent and the excess of the orthoester were removed by rotary evaporation (40° C./≧10 mbar)
3. customthe resulting 11.9 (100%) beige, crystalline residue was crystallized from 120 ml hot isopropyl acetate yielding
4. stirringafter stirring at −20° C. for 17 h 8.4 g (71%) beige product, [α]D=10.8 (CHCl3; c=1)

ORD record

ord-3882a37b3313429d9969b5c5f21228d0

Source dataset

uspto-grants-2007_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07312343B2