Hydrochloric Acid → HCID 69516592, compound

Participants

Reaction Steps

Part A. 1-(4-Chlorocarbonyl-phenyl)-cyclopropanecarboxylic acid methyl ester (0.66 g, 2.77 mmol) was stirred in CH2Cl2 (10 mL) at rt under N2. 1,2-Cis-diamino-cyclohexane (0.66 mL, 2.0 eq) was added as one portion. The mixture was stirred for 10 min. Diluted HCl was added. The mixture was extracted with EtOAc (2×). The aqueous layer was basified with conc. NaOH, extracted with EtOAc (2×). The organic layers were washed with H2O and brine, dried over MgSO4, filtered, and concentrated to afford 1-[4-(2-amino-cyclohexylcarbamoyl)-phenyl]-cyclopropanecarboxylic acid methyl ester (0.35 g, yield: 39.8%). LC/MS (ESI+) 317.4 (M+H).

Provenance & Evidence