Ethyl 1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo(3,4-c)pyridine-3-carboxylate → HCID 69516912, compound

Participants

Reaction Steps

Part A. Following procedure similar to that of Part C in Example 220 but using 1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester and [1-(4-iodo-phenyl)-cyclopropyl]-acetic acid tert-butyl ester as starting materials, 6-[4-(1-tert-butoxycarbonylmethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester was obtained (406.29 mg, yield: 86%). 1H NMR (CDCl3) δ 7.48 (d, J=8.9 Hz, 2H), 7.33 (d, J=8.5 Hz, 2H), 7.22 (d, J=8.5 Hz, 2H), 6.91 (d, J=8.9 Hz, 2H), 4.47 (q, J=7.1 Hz, 2H), 4.12 (m, 2H), 3.81 (s, 3H), 3.32 (t, J=6.6 Hz, 2H), 2.50 (s, 2H), 1.44 (t, J=7.1 Hz, 3H), 1.38 (s, 9H), 0.90 (s, 4H) ppm. LRMS (ESI) 546.2 (M+H).

Provenance & Evidence