反应详情

A mixture of N-(4-tert-butylphenyl)-7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine (0.359 g, 0.96 mmol), prepared as described in Example 2, ammonium formate (0.304 g, 4.82 mmol) and palladium (10% wt. on activated carbon, 40 mg) in MeOH (5 mL) was stirred at r.t. for 1 h and then at 60° C. for 2 h. The mixture was cooled to r.t. and filtered over celite. The filtrate was concentrated under reduced pressure to give a white solid which was dissolved in water. The mixture was extracted twice with a 3:1 mixture of chloroform:isopropanol. The combined organic extracts were dried over sodium sulfate and concentrated to dryness to give 0.26 g of the title compound which was used directly without further purification.

1. customprepared
2. waitat 60° C. for 2 h
3. temperatureThe mixture was cooled to r.t.
4. filtrationfiltered over celite
5. concentrationThe filtrate was concentrated under reduced pressure
6. customto give a white solid which
7. extractionThe mixture was extracted twice with a 3:1 mixture of chloroform
8. dry with materialThe combined organic extracts were dried over sodium sulfate
9. concentrationconcentrated to dryness