4-Tert-Butylaniline → N-(4-tert-Butylphenyl)-7-benzyl-5,6,7,8-tetrahydro-2-(methoxymethyl)pyrido[3,4-d]pyrimidin-4-amine

HRID 971194Notes

Reaction equation

HRID 971194 reaction equation
[CH2:1]([N:8]1[CH2:17][CH2:16][C:15]2[C:14](Cl)=[N:13][C:12]([CH2:19][O:20][CH3:21])=[N:11][C:10]=2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:22]([C:26]1[CH:31]=[CH:30][C:29]([NH2:32])=[CH:28][CH:27]=1)([CH3:25])([CH3:24])[CH3:23]>C(#N)C>[C:22]([C:26]1[CH:27]=[CH:28][C:29]([NH:32][C:14]2[C:15]3[CH2:16][CH2:17][N:8]([CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[CH2:9][C:10]=3[N:11]=[C:12]([CH2:19][O:20][CH3:21])[N:13]=2)=[CH:30][CH:31]=1)([CH3:25])([CH3:23])[CH3:24]

Participants

4

Reactant 2

HCID 698614-Tert-ButylanilineHCID 590215757-Benzyl-4-chloro-5,6,7,8-tetrahydro-2-(methoxymethyl)pyrido[3,4-d]pyrimidine

Product 1

HCID 59021540N-(4-tert-Butylphenyl)-7-benzyl-5,6,7,8-tetrahydro-2-(methoxymethyl)pyrido[3,4-d]pyrimidin-4-amineYield 66%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound was prepared using the general procedure set forth in Example 2, above, using 7-benzyl-4-chloro-5,6,7,8-tetrahydro-2-(methoxymethyl)pyrido[3,4-d]pyrimidine (0.583 g, 1.92 mmol), 4-tert-butylbenzenamine (0.33 mL, 2.11 mmol) and acetonitrile (3 mL) to give 0.524 g (66%) of the title compound as an off-white powder.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-30cbb5c19a0f479f9d39803d196d7e8b
Source dataset
uspto-grants-2007_12
Patent number
US07312330B2

Reaction notes

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