Potassium Carbonate → (4-tert-Butyl-phenyl)-[7-(3-chloro-pyridin-2-yl)-2-methoxymethyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amine hydrochloride

Participants

Reaction Steps

The title compound was prepared using the general procedure set forth in Example 3.B. using N-(4-tert-butylphenyl)-5,6,7,8-tetrahydro-2-(methoxymethyl)pyrido[3,4-d]pyrimidin-4-amine (0.105 g, 0.32 mmol), 2,3-dichloropyridine (0.071 g, 0.48 mmol), potassium carbonate (0.13 g, 0.96 mmol) and DMF (2 mL) and heating the reaction mixture for 1 h. The title compound was obtained as a light yellow solid after formation and isolation of its hydrochloride salt (15 mg)

Provenance & Evidence