4-Tert-Butylaniline → HCID 59021554, compound

HRID 971206Notes

Reaction equation

HRID 971206 reaction equation
[CH2:1]([N:8]1[CH2:17][CH2:16][C:15]2[C:14](Cl)=[N:13][C:12]([CH2:19][N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[N:11][C:10]=2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:26]([C:30]1[CH:36]=[CH:35][C:33]([NH2:34])=[CH:32][CH:31]=1)([CH3:29])([CH3:28])[CH3:27]>C(#N)C>[C:26]([C:30]1[CH:31]=[CH:32][C:33]([NH:34][C:14]2[C:15]3[CH2:16][CH2:17][N:8]([CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[CH2:9][C:10]=3[N:11]=[C:12]([CH2:19][N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[N:13]=2)=[CH:35][CH:36]=1)([CH3:29])([CH3:27])[CH3:28]

Participants

4

Reactant 2

HCID 698614-Tert-ButylanilineHCID 59021535HCID 59021535, compound

Product 1

HCID 59021554HCID 59021554, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
180 °C

Procedure

A mixture of 7-Benzyl-4-chloro-5,6,7,8-tetrahydro-2-(morpholinomethyl)pyrido[3,4-d]pyrimidine (358 mg, 1 mmol) and 4-tert-butylaniline (179 mg, 1.2 mmol) in acetonitrile (2 mL) was heated via microwave in a sealed tube at 180° C. for 5 min. Solvent was removed and the residue was dissolved in water, extracted by ethyl acetate, dried over sodium sulfate and purified by column chromatography. The desired product was obtained as a white foam (120 mg).

Workup

  1. customSolvent was removed
  2. dissolutionthe residue was dissolved in water
  3. extractionextracted by ethyl acetate
  4. dry with materialdried over sodium sulfate
  5. custompurified by column chromatography

Sources & evidence

ORD record
ord-25ab74de10b84e83922c0ca993f6640e
Source dataset
uspto-grants-2007_12
Patent number
US07312330B2

Reaction notes

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