N,N-Dimethylaniline → HCID 69221623, compound

Participants

Reaction Conditions

Reaction Steps

N,N-Dimethylaniline (1.4 g, 11.4 mmol) and phosphorus oxychloride (14 g, 91.2 mmol) were added to a solution of 2-amino-7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(4aH)-one (2.9 g, 11.4 mmol) in 1,2-dichloroethane (23 mL, anhydrous) and were stirred in a preheated oil bath at 90° C. for 45 min. The reaction mixture was poured into ice, neutralized by solid sodium carbonate, extracted by ethyl acetate, and the dark brown semi solid was dissolved in methanol. The combined ethyl acetate and methanol solution was dried over sodium sulfate. Solvent was removed in vacuo and product was obtained as a light brown solid (2.6 g).

Provenance & Evidence