2,3-Dichloropyridine → 7-(3-Chloropyridin-2-yl)-N-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-2-(methylthio)pyrido[3,4-d]pyrimidin-4-amine

Participants

Reaction Conditions

Reaction Steps

A mixture of diisopropylethylamine (252 mg, 1.95 mmol), N-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-2-(methylthio)pyrido[3,4-d]pyrimidin-4-amine (443 mg, 1.3 mmol) and 2,3-dichloropyridine (386 mg, 2.6 mmol) in dioxane (5 mL) and N,N-diethylacetamide (0.5 mL) was heated via microwave in a sealed tube at 180° C. for 10 h. Solvent was removed in vacuo and residue was purified by column chromatography. The product was obtained as a beige solid (100 mg).

Provenance & Evidence