4-Tert-Butylaniline → N-(4-tert-Butylphenyl)-7-benzyl-5,6,7,8-tetrahydro-2-(methylthio)pyrido[3,4-d]pyrimidin-4-amine

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Reaction Steps

The solution of 7-benzyl-4-chloro-5,6,7,8-tetrahydro-2-(methylthio)pyrido[3,4-d]pyrimidine (915 mg, 3 mmol) from Example 24. B. and 4-tert-butylaniline (537 mg, 3.6 mmol) in acetonitrile (5 mL) was heated in a sealed tube via microwave at 180° C. for 10 min. Solid thus formed was filtered out and washed with hexanes. Product was obtained as a light brown solid (750 mg).

Provenance & Evidence