Sodium Iodide → HCID 12003975, compound

Participants

Reaction Conditions

Reaction Steps

Sodium iodide (434 mg, 2.9 mmol) and hydriodic acid (0.4 mL, 47% aqueous solution) were added to a mixture of 7-benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine (500 mg, 1.93 mmol) and 3-aminoquinoline (418 mg, 2.9 mmol) in dioxane (4 mL) and the reaction solution was heated in a sealed tube via microwave at 150° C. for 20 min. The solvent was removed under reduced pressure. The residue was suspended in water, solid sodium carbonate was added to a pH>8, and the mixture was extracted with ethyl acetate. The organic layer was removed in vacuo and the residue was purified by column chromatography to yield the product as a beige solid (405 mg).

Provenance & Evidence