反应详情

A mixture of 4-chloro-7-(3-chloropyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine (40 mg, 0.14 mmol), 2-(4-aminophenyl)-2-methylpropanenitrile (100 mg, 0.63 mmol) (prepared according to the reference: Axton, C. A. et al, J. Chem. Soc. Perkin Trans. 1, 1992, 2203.), and acetonitrile (0.5 mL) was heated in a sealed tube via microwave at 180° C. for 60 min. The solvent was removed in vacuo and the residue was purified by chromatography to give a light yellow solid (50 mg).

1. customprepared
2. customThe solvent was removed in vacuo
3. customthe residue was purified by chromatography