2-(4-Aminophenyl)-2-methylpropanenitrile → HCID 12004067, compound

HRID 971247Notes

Reaction equation

HRID 971247 reaction equation
Cl[C:2]1[C:3]2[CH2:11][CH2:10][N:9]([C:12]3[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][N:13]=3)[CH2:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([CH3:30])([CH3:29])[C:27]#[N:28])=[CH:22][CH:21]=1>C(#N)C>[Cl:18][C:17]1[C:12]([N:9]2[CH2:10][CH2:11][C:3]3[C:2]([NH:19][C:20]4[CH:21]=[CH:22][C:23]([C:26]([CH3:30])([CH3:29])[C:27]#[N:28])=[CH:24][CH:25]=4)=[N:7][CH:6]=[N:5][C:4]=3[CH2:8]2)=[N:13][CH:14]=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 100578012-(4-Aminophenyl)-2-methylpropanenitrileHCID 590214784-Chloro-7-(3-chloropyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Product 1

HCID 12004067HCID 12004067, compoundYield 88.2%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 4-chloro-7-(3-chloropyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine (40 mg, 0.14 mmol), 2-(4-aminophenyl)-2-methylpropanenitrile (100 mg, 0.63 mmol) (prepared according to the reference: Axton, C. A. et al, J. Chem. Soc. Perkin Trans. 1, 1992, 2203.), and acetonitrile (0.5 mL) was heated in a sealed tube via microwave at 180° C. for 60 min. The solvent was removed in vacuo and the residue was purified by chromatography to give a light yellow solid (50 mg).

Workup

  1. customprepared
  2. customThe solvent was removed in vacuo
  3. customthe residue was purified by chromatography

Sources & evidence

ORD record
ord-f4f3fd826ec148889d9216706047be79
Source dataset
uspto-grants-2007_12
Patent number
US07312330B2

Reaction notes

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