HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 971250Generated: October 29, 2026
Diisopropylethylamine → N-(4-(Trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-7-(3-(methylsulfonyl)pyridin-2-yl)-2-(methylthio)pyrido[3,4-d]pyrimidin-4-amine
https://huagongshe.com/reaction/971250
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Chloro-3-(methanesulfonyl)pyridine | HCID 12513746 | — |
| Reactant | N-(4-(Trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-2-(methylthio)pyrido[3,4-d]pyrimidin-4-amine | HCID 59021576 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | N-(4-(Trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-7-(3-(methylsulfonyl)pyridin-2-yl)-2-(methylthio)pyrido[3,4-d]pyrimidin-4-amine | HCID 59021572 | 52.2% |
Reaction Steps
N-(4-(Trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-2-(methylthio)pyrido[3,4-d]pyrimidin-4-amine (320 mg, 0.00089 mol) and 2-chloro-3-(methylsulfonyl)pyridine (200.0 mg, 0.0009915 mol) were dissolved in dioxane (5 mL) and DMA (0.5 mL), N,N-diisopropylethylamine (0.17 g, 0.0013 mol) was added and the mixture was heated in a sealed tube via microwave at 150° C. for 30 min. Solvent was removed and the residue was purified by flash chromatography over silica gel to obtain the product as a white solid (230 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07312330B2 |
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| Source dataset | uspto-grants-2007_12 |
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| ORD ID | ord-875d9481f3bd4ac09443ece09b59bc8c |
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| Source note | uspto-grants-2007_12 |
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