Sodium Iodide → HCID 12004129, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-chloro-7-(3-chloropyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine (0.095 g, 0.00034 mol), 2,3-dihydrobenzo[b][1,4]dioxin-6-amine (0.10 g, 0.00068 mol) and sodium iodide (0.02 g, 0.0001 mol) in acetonitrile was heated at 150° C. by microwave in a sealed tube for 10 minutes. After cooling to r.t., the mixture was poured into saturated sodium bicarbonate and extracted with ethyl acetate. The organic layer was washed with brine and dried over magnesium sulfate and concentrated to leave an oil. Residue purified by flash chromatography over silica gel (ethyl acetate/hexane gradient 0 to 100%) to give 0.110 g of a white solid.

Provenance & Evidence