HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoroaniline → N-({[(3,4-Dimethoxyphenyl)sulfonyl]-4-fluoroanilino}acetyl)valine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoroaniline | HCID 9731 | — |
| Reactant | Methyl bromoacetate | HCID 60984 | — |
| Reactant | 3,4-Dimethoxybenzenesulfonyl chloride | HCID 2734183 | — |
| Reactant | Fmoc-N-methyl-DL-valine | HCID 5164404 | — |
| Product | N-({[(3,4-Dimethoxyphenyl)sulfonyl]-4-fluoroanilino}acetyl)valine | HCID 68614109 | — |
Reaction Steps
Following the general method as outlined in Example 75, starting from N-fmoc-3-methyl-2-methylamino-butyric acid, methyl bromoacetate, 4-fluoroaniline and 3,4-dimethoxybenzenesulfonyl chloride, the title compound was obtained in >60% purity by LC/MS. (ESI+): 483.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07312358B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-849b9a9290564240a2825ddaf8e03dab |
| Source note | uspto-grants-2007_12 |