Benzoyl chloride → 33006-00-7

HRID 971380Notes

Reaction equation

HRID 971380 reaction equation
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:10]1[CH:14]=[CH:13][CH:12]=[C:11]1[CH2:15][C:16]([OH:18])=[O:17]>C(Cl)(Cl)Cl>[C:1]([C:14]1[S:10][C:11]([CH2:15][C:16]([OH:18])=[O:17])=[CH:12][CH:13]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 159702-Thiopheneacetic acid

Product 1

HCID 375176333006-00-7Yield 50%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Using the procedure of Example 1, 8.45 gm of benzoyl chloride, 7.1 gm of thiophene-2-acetic acid [prepared by process of Cagniant, Bull. Soc. Chim., 1949, p.847] and 18 gm aluminum alumina chloride suspended in chloroform were reacted to obtain, after crystallization, a 50% yield of 5-benzoyl-thiophene-2-acetic acid melting at 144° C. The product occurred in the form of colorless crystals insoluble in water.

Workup

  1. customprepared by process of Cagniant, Bull
  2. customwere reacted
  3. customto obtain
  4. customafter crystallization

Sources & evidence

ORD record
ord-44f1c883982f4ece8f2af6289d250fe2
Source dataset
uspto-grants-1979_07
Patent number
US04159986

Reaction notes

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