Methanol → HCID 53942064, compound

Participants

Reaction Steps

9.8 gm of raw 5-benzoyl-thiophene-3-acetic acid were dissolved in 150 cc of methanol. A stream of gaseous hydrochloric acid was bubbled through this solution until the same was saturated. The methanol was evaporated and the residue was taken up in ether. The ethereal phase was washed with an aqueous 10% potassium carbonate solution, then with water until the wash waters were neutral. Thereafter, the ethereal phase was dried over magnesium sulfate, treated with carbon black, filtered and the ether was evaporated. After distillation, 5.45 gm of methyl 5-benzoyl-thiophene-3-acetate were obtained in the form of a colorless liquid, soluble in ether and insoluble in water, boiling at 170° -172° C. under 0.2 mm of Hg.

Provenance & Evidence