HCID 131711528, compound → HCID 131711527, compound

HRID 971392Notes

Reaction equation

HRID 971392 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:11]([NH:13][C@H:14]([C:19]([NH:21][C@H:22]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH:24]([CH3:26])[CH3:25])=[O:20])[C@H:15]([CH2:17][CH3:18])[CH3:16])=[O:12])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1>C(O)C.[Pd]>[NH2:1][C@H:2]([C:11]([NH:13][C@H:14]([C:19]([NH:21][C@H:22]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH:24]([CH3:26])[CH3:25])=[O:20])[C@H:15]([CH2:17][CH3:18])[CH3:16])=[O:12])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 131711528HCID 131711528, compound

Product 1

HCID 131711527HCID 131711527, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

In ethanol (50 ml) is dissolved Z-Tyr-Ile-Leu-OBut (2.09 g, 3.5 m.mols) and catalytic reduction is carried out with palladium black as the catalyst for 4 hours. The catalyst is removed by filtration and the solvent is distilled off, whereby H-Tyr-Ile-Leu-OBut is obtained.

Workup

  1. customThe catalyst is removed by filtration
  2. distillationthe solvent is distilled off

Sources & evidence

ORD record
ord-aa11e6905df548ea90393ff6a272daf7
Source dataset
uspto-grants-1979_07
Patent number
US04159979

Reaction notes

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