HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 5-(Trifluoromethyl)oxindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | HCID 20289277 | HCID 20289277 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(Trifluoromethyl)oxindole | HCID 3734457 | — |
Reaction Steps
A mixture of 4.0 g. of 5-trifluoromethyl-3-methylthio-oxindole, 20 g. of Raney Nickel and 100 ml. of methanol is refluxed for 4 days, cooled, treated with methylene chloride, filtered to remove the Raney Nickel and the filtrate concentrated in vacuo to obtain 5-trifluoromethyl-oxindole, m.p. 188°-190° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04160032 |
| Source dataset | uspto-grants-1979_07 |
| ORD ID | ord-53874bba8b77431c8985de867ba5b9ed |
| Source note | uspto-grants-1979_07 |