Hydrochloric Acid → HCID 131711553, compound

Participants

Reaction Steps

Sulphuric acid (d. 1.84, 18 ml) was added dropwise over 10 min. to an ice-cold stirred suspension of potassium cyanide (9.5 g) and 4-(4-fluorophenyl)-2-methyl-2-butanol (10.0 g) in chloroform (80 ml). The mixture was allowed to warm to room temperature and was stirred over 20 hr. The mixture was basified with 5 N sodium hydroxide solution and was extracted with chloroform. The solvent was removed to leave a pale yellow oil which was treated with hydrochloric acid (d. 1.18, 30 ml) at reflux for 1 hr. The product (9.0 g) crystallised from the acid solution as colourless plates, m.p. 200°-201°.

Provenance & Evidence