反应详情

Reaction of 2-methyl-5,6,7,8-tetrahydroquinoline with phenyl lithium following the method of Example 1 gave 8-lithio-2-methyl-5,6,7,8-tetrahydroquinoline and 2-lithiomethyl-5,6,7,8-tetrahydroquinoline which were treated in situ with carbon dioxide followed by esterification of the product by refluxing in methanol saturated with dry HCl gas according to the general method described in our copending U.S. Ser. No. 460,265.