HCID 131709967, compound → HCID 131709966, compound

HRID 971544Notes

Reaction equation

HRID 971544 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:10]([NH:12][C@H:13]([C:19]([NH:21][C@H:22]([C:31]([NH:33][C@H:34]([C:42]([O:44][CH3:45])=[O:43])[CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:32])[CH2:23][C:24](=[O:30])[O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:20])[CH2:14][CH2:15][C:16](=[O:18])[NH2:17])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6]>CO.[Pd]>[NH2:1][C@H:2]([C:10]([NH:12][C@H:13]([C:19]([NH:21][C@H:22]([C:31]([NH:33][C@H:34]([C:42]([O:44][CH3:45])=[O:43])[CH2:35][C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)=[O:32])[CH2:23][C:24](=[O:30])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:20])[CH2:14][CH2:15][C:16](=[O:18])[NH2:17])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:7])([CH3:6])[CH3:8]

Participants

4

Reactant 1

HCID 131709967HCID 131709967, compound

Product 1

HCID 131709966HCID 131709966, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4.3 g of Z-Thr(tBu)-Gln-Asp(OtBu)-Phe-OCH3 in 300 ml of methanol are hydrogenated with 1 g of 10% strength palladium on charcoal catalyst in the usual manner and after completion of the hydrogen uptake the mixture is filtered and the filtrate evaporated. The evaporation residue, a solid colourless foam, is employed for the next stage without further purification.

Workup

  1. filtrationafter completion of the hydrogen uptake the mixture is filtered
  2. customthe filtrate evaporated
  3. customThe evaporation residue, a solid colourless foam, is employed for the next stage without further purification

Sources & evidence

ORD record
ord-7bb243947f0d4aedac109f4b5f457e24
Source dataset
uspto-grants-1979_07
Patent number
US04159981

Reaction notes

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