Hydrochloric Acid → HCID 131709984, compound

Participants

Reaction Steps

48.6 g of Z-Asp(OtBu)-Phe-OCH 3 in 700 ml of methanol are decarbobenzoxylated in a duck-shaped flask at room temperature after adding 33.5 ml of 3 N hydrogen chloride in dioxane and 5 g of 10% strength palladium catalyst on charcoal. After the hydrogen uptake has ended the mixture is filtered and the filtrate evaporated. 38.7 g of a white foam are obtained. In a thin layer chromatogram on silica gel in chloroform-methanol (9:1) Rf = 0.60; in chloroform-acetone (1:1) Rf = 0.58; Rf102E = 0.42. The product is employed for the subsequent condensation without additional purification.

Provenance & Evidence