Hydrochloric Acid → Z-Gln-Asn-Phe-OCH3

Participants

Reaction Steps

14.5 g of Z-Gln-ONP and 10.8 g of H-Asn-Phe-OCH3, hydrochloride (Ann. 688, 259 [ 1965]) are dissolved together in 100 ml of dimethylformamide and to the solution 4.55 ml of triethylamine are added slowly. A thick paste forms which is diluted with 50 of dimethylformamide. After a reaction period of 24 hours at room temperature, the batch is filtered and the residue washed with dimethylformamide. The resulting Z-Gln-Asn-Phe-OMe can be recrystallized from much hot dimethylformamide. Melting point, 261°-265° C. (decomp.). [α]D20 = + 11° (c = 0.94 in hexamethylphosphoric acid triamide).

Provenance & Evidence