Z-Thr(tBu)-Gln-Asn-Phe-OCH3 → H-Thr(tBu)-Gln-Asn-Phe-OCH3

HRID 971566Notes

Reaction equation

HRID 971566 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:10]([NH:12][C@H:13]([C:19]([NH:21][C@H:22]([C:27]([NH:29][C@H:30]([C:38]([O:40][CH3:41])=[O:39])[CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[O:28])[CH2:23][C:24](=[O:26])[NH2:25])=[O:20])[CH2:14][CH2:15][C:16](=[O:18])[NH2:17])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6]>CO.[C].[Pd]>[NH2:1][C@H:2]([C:10]([NH:12][C@H:13]([C:19]([NH:21][C@H:22]([C:27]([NH:29][C@H:30]([C:38]([O:40][CH3:41])=[O:39])[CH2:31][C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)=[O:28])[CH2:23][C:24](=[O:26])[NH2:25])=[O:20])[CH2:14][CH2:15][C:16](=[O:18])[NH2:17])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:7])([CH3:6])[CH3:8]

Participants

4

Reactant 1

HCID 131709991Z-Thr(tBu)-Gln-Asn-Phe-OCH3

Product 1

HCID 131709992H-Thr(tBu)-Gln-Asn-Phe-OCH3

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

6.31 g of Z-Thr(tBu)-Gln-Asn-Phe-OCH3 and 700 mg of palladium carbon are hydrogenated together at room temperature in 600 ml of methanol in a shaking vessel. The substance gradually passes into solution. The amorphous evaporation residue is used for the next condensation as it is.

Workup

  1. customThe amorphous evaporation residue is used for the next condensation as it

Sources & evidence

ORD record
ord-845f102fae4e458dbf270ff033d31d22
Source dataset
uspto-grants-1979_07
Patent number
US04159981

Reaction notes

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