HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → (S)-N-Carbobenzyloxy-3-(3,4-diformyloxyphenyl)-2-methylalanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Acetic-formic anhydride | HCID 75269 | — |
| Reactant | (2S)-2-{[(benzyloxy)carbonyl]amino}-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid | HCID 18595367 | — |
| Product | (S)-N-Carbobenzyloxy-3-(3,4-diformyloxyphenyl)-2-methylalanine | HCID 54440584 | 100% |
Reaction Steps
A solution of (S)-N-carbobenzyloxy-3-(3,4-dihydroxyphenyl)-2-methylalanine (0.35 g, 1 mmol) and acetic formic anhydride (0.36 g, 4 mmol) in anhydrous tetrahydrofuran (5 ml) is stirred 24 hours at 20°-25° under dry N2. The solvent is evaporated in vacuo and the residue is dried further at 0.1mm/25° for 2 hours. The product (A) (0.4g, 100%) is obtained as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04160712 |
| Source dataset | uspto-grants-1979_07 |
| ORD ID | ord-3f0910666326437e8a5216fc9950aee0 |
| Source note | uspto-grants-1979_07 |