Methylamine → HCID 178482355, compound

Participants

Reaction Steps

2-Amino-7-chloro-5-phenyl-1H-3-benzazepine hydrochloride (8 g; 0.027 mole) [see Example (e)] in 33% w/w methylamine in ethanol (100 ml) was maintained at 40° for 3 days. The solution was then evaporated to dryness and the residual amine was azeotropically removed with toluene. The residue was treated with dry acetone, acidified with a few drops of ethanolic hydrogen chloride, filtered, and washed with acetone to give the title compound as the hydrochloride. Crystallisation of this hydrochloride from absolute ethanol gave a fine white granular powder; m.p. 318°-320°.

Provenance & Evidence