2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid → Cephalosporanic Acid

Participants

Reaction Steps

Using the same procedure, 4 mmol of 3-methyl-1,2,4-oxadiazol-5-yl-acetic acid and 4 mmol of 7-amino-3-(1-methyltetrazol-5-yl-mercaptomethyl)-3-cephem-4-carboxylic acid (90% purity) in 35 ml of dry acetonitrile and 0.1 ml of N-vinyl-imidazole were reacted for one hour at room temperature and two hours at 50° C. to obtain a 37% yield of almost pure 7-[3-methyl-1,2,4-oxadiazol-5-yl-acetamido]-3-[1-methyltetrazol-5-yl-mercaptomethyl]-3-cephem-4-carboxylic acid with a 41% recovery of the starting cephalosporanic acid.

Provenance & Evidence