HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl chloride → HCID 21313390, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (4-Methoxyphenyl)hydrazine | HCID 77023 | — |
| Reactant | HCID 4433338 | HCID 4433338 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 4-Octanone, 1-chloro- | HCID 10899007 | — |
| Reactant | HCID 21313399 | HCID 21313399 | — |
| Reactant | HCID 21313413 | HCID 21313413 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21313390 | HCID 21313390 | — |
Reaction Steps
1-Benzoyl-3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-butylindole is prepared by reaction of 2-cyclohexylmethylpiperidine with 1-chlorooctan-4-one in ethanol in the presence of anhydrous potassium carbonate; reaction of the resulting 1-(2-cyclohexylmethylpiperidino)octan-4-one with 4-methoxyphenylhydrazine in ethanol; and reaction of the resulting 3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-butylindole with sodium hydride in DMF followed by reaction of the resulting sodium salt with benzoyl chloride all according to the procedure described above in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04160862 |
| Source dataset | uspto-grants-1979_07 |
| ORD ID | ord-2f69df30e976475d9d945fd5ae8388ef |
| Source note | uspto-grants-1979_07 |