化工社化工社 化学情報印刷レポート · 研究参考用
Sodium hydride → 1-(3-Bromo-4-fluorobenzoyl)-3-[2-(2-cyclohexylmethylpiperidino)-ethyl]-5-methoxy-2-methylindole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 3-Bromo-4-fluorobenzoyl chloride | HCID 69598 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | 3-[2-(2-Cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindole | HCID 21313365 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(3-Bromo-4-fluorobenzoyl)-3-[2-(2-cyclohexylmethylpiperidino)-ethyl]-5-methoxy-2-methylindole | HCID 21313348 | — |
反応手順
1-(3-Bromo-4-fluorobenzoyl)-3-[2-(2-cyclohexylmethylpiperidino)-ethyl]-5-methoxy-2-methylindole is prepared by reaction of 3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindole with sodium hydride in DMF and reaction of the resulting sodium salt with 3-bromo-4-fluorobenzoyl chloride following the procedure described above in Example 1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04160862 |
| 出典データセット | uspto-grants-1979_07 |
| ORD ID | ord-852c42f32fc0480bbb66c897f43a2fe6 |
| 出典メモ | uspto-grants-1979_07 |