HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl chloride → HCID 21313407, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 4433338 | HCID 4433338 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | HCID 21313308 | HCID 21313308 | — |
| Reactant | Ethyl 3-(2-chloroethyl)-5,6-dimethoxy-1H-indole-2-carboxylate | HCID 21313344 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21313407 | HCID 21313407 | — |
Reaction Steps
Reaction of 3-(2-chloroethyl)-5,6-dimethoxy-2-carbethoxyindole (U.S. Pat. No. 3,562,278) with 2-cyclohexylmethylpiperidine in refluxing acetone in the presence of sodium carbonate and reaction of the resulting 3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5,6-dimethoxy-2-carbethoxyindole with sodium hydride in DMF followed by reaction of the resulting sodium salt with benzoyl chloride affords 1-benzoyl-3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5,6-dimethoxy-2-carbethoxyindole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04160862 |
| Source dataset | uspto-grants-1979_07 |
| ORD ID | ord-bb62c2d824974b45a047dd98ebac29fd |
| Source note | uspto-grants-1979_07 |