Trifluoroacetic acid → HCID 131711578, compound

Participants

Reaction Conditions

Reaction Steps

BOC-Phe-Thr-Ser-OMe, 6.63 g., is suspended in 67 ml. of trifluoroacetic acid. The mixture is stirred at 25° C. until solution is complete. The solution is cooled to 0° C. and the product precipitated by the addition of 300 ml. of ether and 600 ml. of petroleum ether. The product is filtered, washed with ether:petroleum ether and dried in vacuo. The yield of substantially pure Phe-Thr-Ser-OMe.TFA is 6.4 g.

Provenance & Evidence