Ethylene Oxide → HCID 54374694, compound

HRID 971857Notes

Reaction equation

HRID 971857 reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:18][CH2:17][CH2:16][NH:15]2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:19]1[O:21][CH2:20]1>O>[OH:21][CH2:20][CH2:19][N:15]1[CH2:16][CH2:17][CH2:18][CH:14]1[C:11]1[CH:12]=[CH:13][C:8]([O:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 6354Ethylene OxideHCID 457897032-(4-Phenoxyphenyl)pyrrolidine

Product 1

HCID 54374694HCID 54374694, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

12 parts of 2-(4-phenoxyphenyl) pyrrolidine, 2.2 parts of ethylene oxide and 1 part of water were heated at 80° C. for 5 hours. After cooling, there were obtained 8 parts of 1-β-hydroxyethyl-2-(4-phenoxyphenyl) pyrrolidine, B.P./0.3 mm Hg: 179°-180° C.

Workup

  1. temperatureAfter cooling

Sources & evidence

ORD record
ord-4c4007e61b064a91be13e84e68db57d0
Source dataset
uspto-grants-1979_07
Patent number
US04161529

Reaction notes

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