Loxoprofen → HCID 178460347, compound

Participants

Reaction Steps

To a solution of 1.23 g of 2-[4-(2-oxocyclopentan-1-ylmethyl)phenyl]propionic acid in a mixture of 1.6 ml of acetone and 0.5 ml of water was dropwise added with stirring 2 ml of water containing 0.87 g of L-arginine, the mixture was stirred for 1 hour and acetone and water were removed by distillation under reduced pressure to give 2.1 g of the desired compound, m.p. 101°-110° C.

Provenance & Evidence