反应详情

Three grams of ethyl 2-[4-(2-hydroxyiminocyclohexan-1-ylmethyl)phenyl]propionate and 0.8 g of sodium hydroxide were dissolved in 50 ml of methanol and the solution was allowed to stand at room temperature overnight. To the reaction mixture was added 20 ml of water, methanol was removed by distillation and the residue was acidified with hydrochloric acid to precipitate crystals, which were collected by filtration and recrystallized from a mixture of ether and n-hexane affording 2.1 g of colorless crystals, m.p. 148°-150° C.

1. customwas removed by distillation
2. customto precipitate crystals, which
3. filtrationwere collected by filtration
4. customrecrystallized from a mixture of ether and n-hexane affording 2.1 g of colorless crystals, m.p. 148°-150° C.