HCID 21312549, compound → HCID 21312551, compound

Participants

Reaction Steps

A mixture of 1-benzyl-2-(p-methoxybenzyl)-3-methyl-4-propyl-1,2,5,6-tetrahydropyridine oxalate (377 g.), palladium-on-carbon (10%, 10.0 g.) and ethanol (to make 4,500 ml.) was hydrogenated for thirty minutes under pressure (about 50 p.s.i.g.), then filtered. The filtrate was concentrated, affording 2-(p-methoxybenzyl)-3-methyl-4-propyl-1,2,5,6-tetrahydropyridine oxalate in two crops (196 g. and 35 g.), which melted at 146°-147° C.

Provenance & Evidence