Dimethylformamide → HCID 21312568, compound

Participants

Reaction Steps

13.4 g (0.1 mol) of benzimidazolone are reacted with 50.2 g (0.24 mol) of methyl 6-bromohexanoate in a solvent mixture of 100 ml of dimethylformamide and 100 ml of benzene, 15.2 g of dry potassium carbonate powder being used as the acid acceptor. The reaction is carried out at 98°-99° C., whilst stirring well, the water formed during the reaction being removed azeotropically. Thereafter, the hot reaction mixture is filtered and the filtrate is concentrated to dryness. A yellowish oil (39.0 g), which completely crystallises on standing, is obtained in quantitative yield. The purification can be carried out in the customary manner. The product thus prepared shows a proton magnetic resonance spectrum which agrees with the following structure: ##STR20##

Provenance & Evidence