Sodium borohydride → Indoramin

Participants

Reaction Steps

A suspension of 4-benzamido-1-[2-(3-indolyl)ethyl]-pyridinium bromide (10.5g) and sodium borohydride (2.8 g) in sec-butanol (100 ml) was stirred and refluxed for 6 hours. The reaction mixture was cooled to 25° and diluted with aqueous methanol. The product was separated by filtration and washed with aqueous methanol then with water and finally with methanol, and dried to give the crude title compound. This was purified as described in Example 5 to give the title compound mp 203°-5° C.

Provenance & Evidence