Methylamine → HCID 15308078, compound

Participants

Reaction Steps

31 g (1 mole) of methylamine are added to 18.24 g (0.08 mole) of N-(2-oxo-1-pyrrolidineacetyl)-glycine ethyl ester and the reaction mixture is kept at -20° C. for 8 hours, while stirring. It is then evaporated and the residue is recrystallized from absolute ethanol, 15.7 g. of N-methyl-2-(2-oxo-1-pyrrolidineacetamido)-acetamide being obtained (yield: 92% of theory); M.P. 139°-140° C.

Provenance & Evidence