Isopropylamine → HCID 12801064, compound

HRID 972003Notes

Reaction equation

HRID 972003 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][CH2:7][CH:8]2[CH2:13][N:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:11][C:10](=[O:20])[O:9]2)=[CH:4][CH:3]=1.[CH:23]([NH2:26])([CH3:25])[CH3:24]>O1CCOCC1>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][CH2:7][CH:8]([OH:9])[CH2:13][N:12]([CH2:11][C:10]([NH:26][CH:23]([CH3:25])[CH3:24])=[O:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 203059606-[(4-Chlorophenoxy)methyl]-4-phenylmorpholin-2-one

Product 1

HCID 12801064HCID 12801064, compoundYield 10.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

After 7.0 g (0.22 moles) of 6-(p-chlorophenoxymethyl)-4-phenyl-2-morpholinone and 20 g of isopropylamine were dissolved in 50 ml of dioxane and the resulting Solution was left to stand overnight at room temperature, the reaction mixture was concentrated in vacuo. The residue was solidified by addition of a small amount of ether. The solid was filtered, washed with ether and dried to give 8.7 g of the product. Recrystallization from ethanol afforded 5.5 g (66.3%) of crystals, with a melting point of 140.5° to 142.5°.

Workup

  1. waitthe resulting Solution was left
  2. concentrationthe reaction mixture was concentrated in vacuo
  3. additionThe residue was solidified by addition of a small amount of ether
  4. filtrationThe solid was filtered
  5. washwashed with ether
  6. customdried

Sources & evidence

ORD record
ord-a51548dc85ff449aa968922aa3098828
Source dataset
uspto-grants-1979_07
Patent number
US04162331

Reaction notes

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