Water → HCID 53991412, compound

HRID 972005Notes

Reaction equation

HRID 972005 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][CH:10]([OH:24])[CH2:11][N:12]([CH2:19][C:20]([O:22][CH3:23])=[O:21])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.[C:25](OC(=O)C)(=[O:27])[CH3:26].O>N1C=CC=CC=1>[C:25]([O:24][CH:10]([CH2:11][N:12]([CH2:19][C:20]([O:22][CH3:23])=[O:21])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:9][S:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)(=[O:27])[CH3:26]

Participants

5

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 12801101HCID 12801101, compound

Product 1

HCID 53991412HCID 53991412, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

After 200 mg (0.00054 moles) of 1-(p-chlorophenylthio)-3-(N-carbomethoxymethyl-N-phenylamino)-2-propanol and 1 g of acetic anhydride were dissolved in 3 ml of pyridine and left to stand at room temperature for 20 hr, the reaction mixture was poured into iced water and extracted with ether. The ether layer was washed with 10% hydrochloric acid and water and dried. Evaporation or ether under reduced pressure gave 190 mg (86.5%) of an oily substance.

Workup

  1. waitleft
  2. extractionextracted with ether
  3. washThe ether layer was washed with 10% hydrochloric acid and water
  4. customdried
  5. customEvaporation or ether under reduced pressure
  6. customgave 190 mg (86.5%) of an oily substance

Sources & evidence

ORD record
ord-5823ea7f5a7b419f82223660e6e2fe31
Source dataset
uspto-grants-1979_07
Patent number
US04162331

Reaction notes

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