Potassium Hydroxide → Bis[2-hydroxy-3-(7,7,8,9,9-pentamethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-3-yl)propyl]1,2-cyclohexanedicarboxylate

HRID 972018Notes

Reaction equation

HRID 972018 reaction equation
[CH3:1][C:2]1([CH3:17])[N:13]([CH3:14])[C:12]([CH3:16])([CH3:15])[CH2:11][C:4]2([NH:8][C:7](=[O:9])[NH:6][C:5]2=[O:10])[CH2:3]1.[O:18]1[CH2:37][CH:19]1[CH2:20][O:21][C:22]([CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH:25]1[C:30]([O:32][CH2:33][CH:34]1[O:36][CH2:35]1)=[O:31])=[O:23].[OH-:38].[K+]>CO>[OH:18][CH:19]([CH2:37][N:6]1[C:5](=[O:38])[C:4]2([CH2:3][C:2]([CH3:1])([CH3:17])[N:13]([CH3:14])[C:12]([CH3:16])([CH3:15])[CH2:11]2)[NH:8][C:7]1=[O:9])[CH2:20][O:21][C:22]([CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH:25]1[C:30]([O:32][CH2:33][CH:34]([OH:36])[CH2:35][N:6]1[C:5](=[O:10])[C:4]2([CH2:3][C:2]([CH3:17])([CH3:1])[N:13]([CH3:14])[C:12]([CH3:16])([CH3:15])[CH2:11]2)[NH:8][C:7]1=[O:9])=[O:31])=[O:23]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 21660Cyclohexane-1,2-dicarboxylic acid bis(oxiranylmethyl) esterHCID 204818537,7,8,9,9-Pentamethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione

Product 1

HCID 86736590Bis[2-hydroxy-3-(7,7,8,9,9-pentamethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-3-yl)propyl]1,2-cyclohexanedicarboxylate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

27.0 g of 7,7,8,9,9-pentamethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione, 14.0 g of bis(2,3-epoxypropyl)1,2-cyclohexanedicarboxylate and 0.2 g of potassium hydroxide were reacted in 300 ml of methanol, following substantially the same procedure as in Example 1. The desired Compound No. 147 was obtained in the form of white crystals melting at 119°-122° C.

Sources & evidence

ORD record
ord-a6ab9d8bdb6040da8edf848555b2864a
Source dataset
uspto-grants-1979_07
Patent number
US04162246

Reaction notes

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