2,2-Bis{4-[2-hydroxy-3-(7,7,8,9,9-pentamethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-3-yl)propoxy]phenyl}propane → 2,2-Bis{4-[2-acetoxy-3-(7,7,8,9,9-pentamethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-3-yl)propoxy]phenyl}propane

HRID 972022Notes

Reaction equation

HRID 972022 reaction equation
[OH:1][CH:2]([CH2:42][N:43]1[C:47](=[O:48])[C:46]2([CH2:53][C:52]([CH3:55])([CH3:54])[N:51]([CH3:56])[C:50]([CH3:58])([CH3:57])[CH2:49]2)[NH:45][C:44]1=[O:59])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH:22]([OH:41])[CH2:23][N:24]3[C:28](=[O:29])[C:27]4([CH2:34][C:33]([CH3:36])([CH3:35])[N:32]([CH3:37])[C:31]([CH3:39])([CH3:38])[CH2:30]4)[NH:26][C:25]3=[O:40])=[CH:16][CH:15]=2)([CH3:13])[CH3:12])=[CH:7][CH:6]=1>C(OC(=O)C)(=O)C>[C:2]([O:41][CH:22]([CH2:23][N:24]1[C:28](=[O:29])[C:27]2([CH2:34][C:33]([CH3:35])([CH3:36])[N:32]([CH3:37])[C:31]([CH3:38])([CH3:39])[CH2:30]2)[NH:26][C:25]1=[O:40])[CH2:21][O:20][C:17]1[CH:18]=[CH:19][C:14]([C:11]([C:8]2[CH:7]=[CH:6][C:5]([O:4][CH2:3][CH:2]([O:1][C:5](=[O:4])[CH3:6])[CH2:42][N:43]3[C:47](=[O:48])[C:46]4([CH2:53][C:52]([CH3:55])([CH3:54])[N:51]([CH3:56])[C:50]([CH3:58])([CH3:57])[CH2:49]4)[NH:45][C:44]3=[O:59])=[CH:10][CH:9]=2)([CH3:13])[CH3:12])=[CH:15][CH:16]=1)(=[O:1])[CH3:3]

Participants

3

Reactant 1

HCID 203967802,2-Bis{4-[2-hydroxy-3-(7,7,8,9,9-pentamethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-3-yl)propoxy]phenyl}propane

Product 1

HCID 203968012,2-Bis{4-[2-acetoxy-3-(7,7,8,9,9-pentamethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-3-yl)propoxy]phenyl}propane

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A mixture of 4.0 g of 2,2-bis{4-[2-hydroxy-3-(7,7,8,9,9-pentamethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-3-yl)propoxy]phenyl}propane, obtained as described in Example 1, and 100 ml of acetic anhydride was heated at 120°-130° C. for 6 hours. The reaction mixture was then treated substantially as described in Example 13, to give the desired Compound No. 35 in the form of white crystals melting at 229°-237° C.

Workup

  1. customobtained
  2. temperaturewas heated at 120°-130° C. for 6 hours
  3. additionThe reaction mixture was then treated substantially

Sources & evidence

ORD record
ord-94a7b6b621ff4802a940ae361f24b65d
Source dataset
uspto-grants-1979_07
Patent number
US04162246

Reaction notes

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